Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy
نویسندگان
چکیده
منابع مشابه
Lung-derived innate cytokines: new epigenetic targets of allergen-specific sublingual immunotherapy
Objective(s):Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. Materials and Methods:BALB/c...
متن کاملEconomic evaluation of sublingual vs subcutaneous allergen immunotherapy.
BACKGROUND Sublingual allergen immunotherapy (SLIT) is a commonly used alternative route of administration to standard subcutaneous immunotherapy (SCIT) in Europe. Despite its wide use, the cost-effectiveness of SLIT vs SCIT has not been well established. OBJECTIVE To evaluate the cost and effectiveness of SLIT compared with SCIT in patients with allergic rhinoconjunctivitis during a 3-year s...
متن کاملA novel approach in allergen-specific immunotherapy: combination of sublingual and subcutaneous routes.
BACKGROUND Subcutaneous allergen-specific immunotherapy (SIT) has an early onset of action, whereas repeated injections and safety concerns have limited its use in the pediatric age group. Meanwhile, the improved safety profile of the sublingual route has been accepted as an alternative despite its relatively late onset of action. OBJECTIVE We sought to improve the efficacy and safety of SIT ...
متن کاملSpecific IgE response to different grass pollen allergen components in children undergoing sublingual immunotherapy
UNLABELLED BACKGROUND Grass pollen is a major cause of respiratory allergy worldwide and contain a number of allergens, some of theme (Phl p 1, Phl p 2, Phl p 5, and Phl 6 from Phleum pratense, and their homologous in other grasses) are known as major allergens. The administration of grass pollen extracts by immunotherapy generally induces an initial rise in specific immunoglobulin E (sIgE) ...
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Background TRAIL is present in cells involved in asthma including eosinophils, mast cells, fibroblasts, and airway epithelial cells. It is expressed in airway remodeling and may be linked with the pathways of transforming growth factorbeta1, which is thought to cause damage to the epithelium. The repair process of the epithelium is hindered as a result of increased apoptosis induced by TGF-beta...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2021
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2021.03.030